Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies: Design, Development And Implementation
Identifieur interne : 000659 ( Main/Exploration ); précédent : 000658; suivant : 000660Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies: Design, Development And Implementation
Auteurs : D. J. Cohen ; A. Cheng [République populaire de Chine] ; A. Kahn [Israël] ; M. Aviram [Israël] ; A. J. Whitehead ; S. L. Hyzy ; R. M. Clohessy ; B. D. Boyan ; Z. SchwartzSource :
- Scientific Reports [ 2045-2322 ] ; 2016.
Abstract
Custom devices supporting bone regeneration and implant placement are needed for edentulous patients with large mandibular deficiencies where endosteal implantation is not possible. We developed a novel subperiosteal titanium-aluminum-vanadium bone onlay device produced by additive manufacturing (AM) and post-fabrication osteogenic micro-/nano-scale surface texture modification. Human osteoblasts produced osteogenic and angiogenic factors when grown on laser-sintered nano-/micro-textured surfaces compared to smooth surfaces. Surface-processed constructs caused higher bone-to-implant contact, vertical bone growth into disk pores (microCT and histomorphometry), and mechanical pull-out force at 5 and 10 w on rat calvaria compared to non surface-modified constructs, even when pre-treating the bone to stimulate osteogenesis. Surface-modified wrap-implants placed around rabbit tibias osseointegrated by 6 w. Finally, patient-specific constructs designed to support dental implants produced via AM and surface-processing were implanted on edentulous mandibular bone. 3 and 8 month post-operative images showed new bone formation and osseointegration of the device and indicated stability of the dental implants.
Url:
DOI: 10.1038/srep20493
PubMed: 26854193
PubMed Central: 4745084
Affiliations:
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Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University</institution>, Atlanta,<country>GA</country>,<country>U.S.A</country></nlm:aff><wicri:noCountry code="nlm country">GA</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Biomedical Engineering, Peking University</institution>, Beijing,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kahn, A" sort="Kahn, A" uniqKey="Kahn A" first="A." last="Kahn">A. 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J." last="Cohen">D. J. Cohen</name><affiliation><nlm:aff id="a1"><institution>Department of Biomedical Engineering, Virginia Commonwealth University</institution>, Richmond,<country>VA</country>,<country>U.S.A</country></nlm:aff><wicri:noCountry code="nlm country">VA</wicri:noCountry></affiliation></author><author><name sortKey="Cheng, A" sort="Cheng, A" uniqKey="Cheng A" first="A." last="Cheng">A. Cheng</name><affiliation><nlm:aff id="a2"><institution>Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University</institution>, Atlanta,<country>GA</country>,<country>U.S.A</country></nlm:aff><wicri:noCountry code="nlm country">GA</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Biomedical Engineering, Peking University</institution>, Beijing,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kahn, A" sort="Kahn, A" uniqKey="Kahn A" first="A." last="Kahn">A. Kahn</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Oral and Maxillofacial Surgery, Tel Aviv University</institution>, Tel Aviv,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aviram, M" sort="Aviram, M" uniqKey="Aviram M" first="M." last="Aviram">M. Aviram</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Tipul Behiuch Private Clinic</institution>, Tel Aviv,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Whitehead, A J" sort="Whitehead, A J" uniqKey="Whitehead A" first="A. J." last="Whitehead">A. J. 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Clohessy</name><affiliation><nlm:aff id="a1"><institution>Department of Biomedical Engineering, Virginia Commonwealth University</institution>, Richmond,<country>VA</country>,<country>U.S.A</country></nlm:aff><wicri:noCountry code="nlm country">VA</wicri:noCountry></affiliation></author><author><name sortKey="Boyan, B D" sort="Boyan, B D" uniqKey="Boyan B" first="B. D." last="Boyan">B. D. Boyan</name><affiliation><nlm:aff id="a1"><institution>Department of Biomedical Engineering, Virginia Commonwealth University</institution>, Richmond,<country>VA</country>,<country>U.S.A</country></nlm:aff><wicri:noCountry code="nlm country">VA</wicri:noCountry></affiliation><affiliation><nlm:aff id="a2"><institution>Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University</institution>, Atlanta,<country>GA</country>,<country>U.S.A</country></nlm:aff><wicri:noCountry code="nlm country">GA</wicri:noCountry></affiliation></author><author><name sortKey="Schwartz, Z" sort="Schwartz, Z" uniqKey="Schwartz Z" first="Z." last="Schwartz">Z. Schwartz</name><affiliation><nlm:aff id="a1"><institution>Department of Biomedical Engineering, Virginia Commonwealth University</institution>, Richmond,<country>VA</country>,<country>U.S.A</country></nlm:aff><wicri:noCountry code="nlm country">VA</wicri:noCountry></affiliation><affiliation><nlm:aff id="a6"><institution>Department of Periodontics, University of Texas Health Science Center at San Antonio</institution>, San Antonio,<country>TX</country>,<country>U.S.A</country></nlm:aff><wicri:noCountry code="nlm country">TX</wicri:noCountry></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Custom devices supporting bone regeneration and implant placement are needed for edentulous patients with large mandibular deficiencies where endosteal implantation is not possible. We developed a novel subperiosteal titanium-aluminum-vanadium bone onlay device produced by additive manufacturing (AM) and post-fabrication osteogenic micro-/nano-scale surface texture modification. Human osteoblasts produced osteogenic and angiogenic factors when grown on laser-sintered nano-/micro-textured surfaces compared to smooth surfaces. Surface-processed constructs caused higher bone-to-implant contact, vertical bone growth into disk pores (microCT and histomorphometry), and mechanical pull-out force at 5 and 10 w on rat calvaria compared to non surface-modified constructs, even when pre-treating the bone to stimulate osteogenesis. Surface-modified wrap-implants placed around rabbit tibias osseointegrated by 6 w. Finally, patient-specific constructs designed to support dental implants produced via AM and surface-processing were implanted on edentulous mandibular bone. 3 and 8 month post-operative images showed new bone formation and osseointegration of the device and indicated stability of the dental implants.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dye, B A" uniqKey="Dye B">B. A. Dye</name></author><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Beltran Aguilar, E D" uniqKey="Beltran Aguilar E">E. D. Beltran-Aguilar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Douglass, C W" uniqKey="Douglass C">C. W. Douglass</name></author><author><name sortKey="Shih, A" uniqKey="Shih A">A. Shih</name></author><author><name sortKey="Ostry, L" uniqKey="Ostry L">L. 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